![Ethyl 5-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]-1,2-oxazole-3-carboxylate structure](https://static.chemtradehub.com/structs/253/253196-37-1-8450.webp "Ethyl 5-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]-1,2-oxazole-3-carboxylate structure")
Ethyl 5-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]-1,2-oxazole-3-carboxylate
CAS Number:
253196-37-1
Molecular Formula:
C12H18N2O5
Photoredox-catalyzed direct C(sp2)–H difluoromethylation of enamides or heterocycles with [bis(difluoroacetoxy)iodo]benzene
Literature Information
Publication Date
2021-08-24
DOI
10.1039/D1QO00995H
Impact Factor
5.281
Authors
Yun Zhao, Yan Zhang, Yating Liu, Tonghao Zhu
View Original
Abstract
A photoredox-catalyzed direct C(sp2)–H difluoromethylation of enamides is accomplished by using easily accessible [bis(difluoroacetoxy)iodo]benzene as the CF2H source. Diverse (E)-β-difluoromethylated enamides are obtained in moderate to good yields by using this protocol under visible light irradiation. A range of sensitive functional groups can be compatible under these conditions. Additionally, C(sp2)–H difluoromethylation of heterocycles is demonstrated. Moreover, this method is applied in the gram-scale difluoromethylation of a non-steroidal anti-inflammatory drug piroxicam precursor.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![4-{2-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazino}benzoic acid structure](https://static.chemtradehub.com/structs/214/214475-53-3-bf36.webp "4-{2-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazino}benzoic acid structure")
4-{2-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazino}benzoic acid
CAS Number:
214475-53-3
Molecular Formula:
C22H18N2O4
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