Achievements in fluorination using variable reagents through a deoxyfluorination reaction
Literature Information
Publication Date
2021-08-18
DOI
10.1039/D1QO00952D
Impact Factor
5.281
Authors
Trapti Aggarwal, Sushmita, Akhilesh K. Verma
View Original
Abstract
The fusion of fluorine in drug molecules through different fluorinating reagents remains a cornerstone in pharmaceutical chemistry. Progress in the field of deoxyfluorination through the development of novel reagents has enabled new mechanistic approaches to achieve organic transformations. Methodologies for the incorporation of fluorine into a complex molecule continue to be an important area of research because of the presence of fluorine in a plethora of pharmaceutical active ingredients. In this review, we have summarized the 2011–2021 progress made in the area of deoxyfluorination for the construction of biologically active molecules. The synthetic strategies described in this review provided diversely substituted fluorinated molecules and a few of them have profound pharmacological activity.
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Related Literature
International Union of Chemistry. Fifth Report of the Committee on Atoms
Other
DOI: 10.1039/AN940650568B
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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Molecular Formula:
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