![2-Methyl-2-propanyl 4-[3-(aminomethyl)phenyl]-1-piperazinecarboxylate structure](https://static.chemtradehub.com/structs/889/889948-55-4-5c12.webp "2-Methyl-2-propanyl 4-[3-(aminomethyl)phenyl]-1-piperazinecarboxylate structure")
2-Methyl-2-propanyl 4-[3-(aminomethyl)phenyl]-1-piperazinecarboxylate
CAS Number:
889948-55-4
Molecular Formula:
C16H25N3O2
An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals‡
Literature Information
Publication Date
2021-08-19
DOI
10.1039/D1QO00919B
Impact Factor
5.281
Authors
Sunil V. Sharma, Cristina Pubill-Ulldemolins, Enrico Marelli, Rebecca J. M. Goss
View Original
Abstract
The development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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