A solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging
Literature Information
Publication Date
2021-04-26
DOI
10.1039/D1QO00350J
Impact Factor
5.281
Authors
Xiaoyun Ran, Qian Zhou, Jin Zhang, Shanqiang Wang, Gui Wang, Hui Yang, Xiaochun Liu, Zhouyu Wang
View Original
Abstract
Starting from citric acid (CA) and ethylenediamine derivatives, a solvent-free, catalyst-free and high yielding synthesis approach for bicyclic 2-pyridones is presented. By continuously modifying the core structure, a series of novel and bright fluorophores with outstanding endoplasmic reticulum targeting properties (Pearson's coefficients = 0.89–0.97) and antibacterial activities were obtained. Theoretical calculations and single-crystal structures were further investigated to help reveal the structure–activity relationship. The green preparation method and excellent biological properties make these bicyclic 2-pyridone derivatives very promising for future applications.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(1H-Benzotriazol-1-yloxy)(di-1-pyrrolidinyl)methylium hexafluorophosphate
CAS Number:
105379-24-6
Molecular Formula:
C15H21F6N5OP
![1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione structure](https://static.chemtradehub.com/structs/57-/57-96-5-efcc.webp "1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione structure")
1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
CAS Number:
57-96-5
Molecular Formula:
C23H20N2O3S
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