8-Methyl-2-pyridin-4-ylquinoline-4-carboxylic acid
CAS Number:
107027-42-9
Molecular Formula:
C16H12N2O2
A mimotope attached to an ITIM–SHP-1 interaction inhibitory peptide boosts immune response and efficacy
Literature Information
Publication Date
2021-05-19
DOI
10.1039/D1MD00099C
Impact Factor
0
Authors
Koushik Roy, Syamal Roy, Siddhartha Roy
View Original
Abstract
Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both stimulatory and damping components. A malarial parasite-derived conformation-constrained peptide was conjugated to a signal-damping pathway inhibitor. Mice immunized with this antigen produced higher antibody levels which delayed parasitemia. This represents a new approach to antigen design.
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2-morpholino-2-[2-(trifluoromethyl)pyrimidin-5-yl]ethanamine
CAS Number:
1192570-20-9
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