Understanding the molecular mechanisms of transcriptional bursting
Literature Information
Publication Date
2021-09-16
DOI
10.1039/D1CP03665C
Impact Factor
3.676
Authors
Alena Klindziuk, Anatoly B. Kolomeisky
View Original
Abstract
In recent years, it has been experimentally established that transcription, a fundamental biological process that involves the synthesis of messenger RNA molecules from DNA templates, does not proceed continuously as was expected. Rather, it exhibits a distinct dynamic behavior of alternating between productive phases when RNA molecules are actively synthesized and inactive phases when there is no RNA production at all. The bimodal transcriptional dynamics is now confirmed to be present in most living systems. This phenomenon is known as transcriptional bursting and it attracts significant amounts of attention from researchers in different fields. However, despite multiple experimental and theoretical investigations, the microscopic origin and biological functions of the transcriptional bursting remain unclear. Here we discuss the recent developments in uncovering the underlying molecular mechanisms of transcriptional bursting and our current understanding of them. Our analysis presents a physicochemical view of the processes that govern transcriptional bursting in living cells.
Recommended Journals
Journal of Natural Medicines
Organic Process Research & Development
Russian Journal of Applied Chemistry
Russian Chemical Bulletin
Russian Journal of Bioorganic Chemistry
Journal of Saudi Chemical Society
Russian Journal of General Chemistry
Russian Journal of Organic Chemistry
Chemical Communications
Drug Discovery Today
Related Literature
Unravelling the full relaxation dynamics of superexcited helium nanodroplets
Jakob D. Asmussen, Rupert Michiels, Katrin Dulitz, Aaron Ngai, Ulrich Bangert, Marcel Binz, Lukas Bruder, Miltcho Danailov, Michele Di Fraia, Jussi Eloranta, Raimund Feifel, Luca Giannessi, Oksana Plekan, Kevin C. Prince, Richard J. Squibb, Daniel Uhl, Andreas Wituschek, Carlo Callegari, Frank Stienkemeier, Marcel Mudrich
2021-07-07
Paper
DOI: 10.1039/D1CP01041G
On the thermodynamics of folding of an i-motif DNA in solution under favorable conditions
Jussara Amato, Federica D’Aria, Simona Marzano, Nunzia Iaccarino, Antonio Randazzo, Concetta Giancola, Bruno Pagano
2021-06-16
Paper
DOI: 10.1039/D1CP01779A
Enhancing the yield of calcium carbonate precipitation by obstacles in laminar flow in a confined geometry
Katalin Viktória Bere, Emilie Nez, Edina Balog, László Janovák, Dániel Sebők, Ákos Kukovecz, Clément Roux, Veronique Pimienta, Gábor Schuszter
2021-06-23
Paper
DOI: 10.1039/D1CP01334C
Modulating thermal conductance across the metal/graphene/SiO2 interface with ion irradiation
Yu Zhao, Yi Tao, Wei Xu, Shuyu Huang, Ming Guo, Jingjie Sha, Juekuan Yang, Yunfei Chen
2021-09-21
Paper
DOI: 10.1039/D1CP03563K
Homogeneous nucleation of sheared liquids: advances and insights from simulations and theory
Amrita Goswami, Jayant K. Singh
2021-07-13
Perspective
DOI: 10.1039/D1CP02617H
A review on two-dimensional materials for chemiresistive- and FET-type gas sensors
Lei Liu, Yan Yang, Qingwu Huang, Delong Li, Dawen Zeng
2021-07-02
Perspective
DOI: 10.1039/D1CP01890F
Water–biomolecule clusters studied by photoemission spectroscopy and multilevel atomistic simulations: hydration or solvation?
Giuseppe Mattioli, Lorenzo Avaldi, Paola Bolognesi, John D. Bozek, Mattea C. Castrovilli, Jacopo Chiarinelli, Alicja Domaracka, Suvasthika Indrajith, Sylvain Maclot, Aleksandar R. Milosavljević, Patrick Rousseau
2021-06-25
Paper
DOI: 10.1039/D1CP02031E
Shock wave and modelling study of the unimolecular dissociation of Si(CH3)2F2: an access to spectroscopic and kinetic properties of SiF2
C. J. Cobos
2021-09-23
Paper
DOI: 10.1039/D1CP03298D
You might also like
Compound Q&A
Is 4-Benzyl-2,2-dimethylmorpholine (CAS: 84761-04-6) safe?
4-Benzyl-2,2-dimethylmorpholine is generally considered safe when handled under ...
84761-04-64-Benzyl-2,2-dimethy...
Compound Q&A
What is (5,6-Dimethoxy-3-pyridinyl)boronic acid (CAS: 1346526-61-1)?
(5,6-Dimethoxy-3-pyridinyl)boronic acid is a chemical compound with the molecula...
1346526-61-1(5,6-Dimethoxy-3-pyr...
Compound Q&A
How is 1,1,3,3-Tetramethyl-1,3-bis(2-methyl-2-propanyl)disiloxane (CAS: 67875-55-2) typically synthesized?
1,1,3,3-Tetramethyl-1,3-bis(2-methyl-2-propanyl)disiloxane is synthesized throug...
67875-55-21,1,3,3-Tetramethyl-...
Compound Q&A
What are the main uses of (2R,4S)-1-Boc-4-methylpyrrolidine-2-carboxylic acid (CAS: 1018818-04-6)?
(2R,4S)-1-Boc-4-methylpyrrolidine-2-carboxylic acid is primarily used as a build...
1018818-04-6(2R,4S)-1-Boc-4-meth...
Compound Q&A
What precautions should be taken when handling 2,3-Dichloroacrylonitrile (CAS: 22410-58-8)?
When handling 2,3-Dichloroacrylonitrile, it is crucial to wear appropriate perso...
22410-58-82,3-Dichloroacryloni...
Compound Q&A
How should (S)-1-(o-Tolyl)ethanamine hydrochloride (CAS: 1332832-16-2) be stored?
(S)-1-(o-Tolyl)ethanamine hydrochloride should be stored in a cool, dry place to...
1332832-16-2(S)-1-(o-Tolyl)ethan...
Compound Q&A
What are the physical and chemical properties of Benzyl [1-(hydroxyamino)-1-imino-2-methyl-2-propanyl]carbamate (CAS: 518047-98-8)?
Benzyl [1-(hydroxyamino)-1-imino-2-methyl-2-propanyl]carbamate (CAS: 518047-98-8...
518047-98-8Benzyl [1-(hydroxyam...
Compound Q&A
What industries use 2-Methyloxazole-5-carbaldehyde (CAS: 885273-42-7)?
2-Methyloxazole-5-carbaldehyde is used in the pharmaceutical industry for the sy...
885273-42-72-Methyloxazole-5-ca...
Compound Q&A
What is the market or research trend for 2-Methyl-2-propanyl 4-[(1S)-1-hydroxyethyl]-1-piperidinecarboxylate (CAS: 389889-82-1)?
The market for 2-Methyl-2-propanyl 4-[(1S)-1-hydroxyethyl]-1-piperidinecarboxyla...
389889-82-12-Methyl-2-propanyl ...
Compound Q&A
Is 1-Butyl-3-methylpyridinium bromide (CAS: 26576-85-2) safe?
1-Butyl-3-methylpyridinium bromide is generally considered safe for laboratory u...
26576-85-21-Butyl-3-methylpyri...
Source Journal
Physical Chemistry Chemical Physics
CiteScore:
5.5
Self-citation Rate:
10.3%
Articles per Year:
3036
Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.
Recommended Compounds
![Ethyl 5-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]-1,2-oxazole-3-carboxylate structure](https://static.chemtradehub.com/structs/253/253196-37-1-8450.webp "Ethyl 5-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]-1,2-oxazole-3-carboxylate structure")
Ethyl 5-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]-1,2-oxazole-3-carboxylate
CAS Number:
253196-37-1
Molecular Formula:
C12H18N2O5
3-(3-Carboxyphenyl)-5-(trifluoromethyl)benzoic acid
CAS Number:
1261930-96-4
Molecular Formula:
C15H9F3O4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.