Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes
Literature Information
Publication Date
2021-01-12
DOI
10.1039/D0QO01471K
Impact Factor
5.281
Authors
Xing Li, Pingan Zhai, Yongsheng Fang, Wenhui Li, Honghong Chang, Wenchao Gao
View Original
Abstract
A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described. This three-component approach features remarkably much broader substrate scope, good functional group tolerance, good to high yields, operational safety and mild reaction conditions, and this method is also catalyst-free, additive-free and operationally simple.
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Organic Chemistry Frontiers
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