![[2',6'-bis(propan-2-yloxy)-[1,1'-biphenyl]-3-yl]dicyclohexylphosphane structure](https://static.chemtradehub.com/structs/787/787618-22-8-dda2.webp "[2',6'-bis(propan-2-yloxy)-[1,1'-biphenyl]-3-yl]dicyclohexylphosphane structure")
[2',6'-bis(propan-2-yloxy)-[1,1'-biphenyl]-3-yl]dicyclohexylphosphane
CAS Number:
787618-22-8
Molecular Formula:
C30H43O2P
The oxa-Michael reaction in the synthesis of 5- and 6-membered oxygen-containing heterocycles
Literature Information
Publication Date
2021-01-19
DOI
10.1039/D0QO01312A
Impact Factor
5.281
Authors
Tauqir Ahmad, Nisar Ullah
View Original
Abstract
The oxa-Michael reaction (OMR) offers the most effective and straightforward route to the synthesis of a wide range of 5- and 6-membered oxygen-containing heterocycles including tetrahydropyrans, tetrahydrofurans, 1,4 dioxanes, isoxazolidines, isoxazolines, γ-lactones and related γ-butenolides. These molecular frameworks are frequently featured in numerous biologically active substances. Moreover, the emergence of organocatalytic asymmetric OMR has empowered access to a variety of diverse oxygen-containing heterocycles in a highly enantio- and/or diastereoselective fashion. This review provides an updated account on the recent advances and applications of OMR in the synthesis 5- and 6-membered monocyclic oxo-heterocycles published in the literature since 2013 to date.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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