Copper-catalyzed alkynylation/annulation cascades of N-allyl ynamides: regioselective access to medium-sized N-heterocycles
Literature Information
Publication Date
2020-09-30
DOI
10.1039/D0QO00837K
Impact Factor
5.281
Authors
Xu-Heng Yang, Jian Huang, Fang Wang, Zhuoliang Liu, Yujiao Li, Cheng-an Tao, Jianfang Wang
View Original
Abstract
A synthetic strategy based on sequential application of aza-Claisen rearrangement, C–H functionalization, C–N coupling and cyclization as key steps has been developed for the synthesis of various medium-sized N-heterocycles of pharmaceutical relevance. This efficient new method exhibits a broad scope and provides a highly efficient synthesis of N-heterocycles of different ring sizes (6-, 7-, 8-, and 9-membered rings) in moderate to good yields.
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Source Journal
Organic Chemistry Frontiers
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