Polymer models for the mechanisms of chromatin 3D folding: review and perspective
Literature Information
Rui Zhou
Recent experiments have provided unprecedented details on the hierarchical organization of the chromatin 3D structure and thus a great opportunity for understanding the mechanisms behind chromatin folding. As a bridge between experimental results and physical theory, coarse-grained polymer models of chromatin are of great value. Here, we review several popular models of chromatin folding, including the fractal globule model, loop models (the random loop model, the dynamic loop model, and the loop extrusion model), the string-and-binder switch model, and the block copolymer model. Physical models are still in great need to explain a larger variety of chromatin folding properties, especially structural features at different scales, their relation to the heterogeneous nature of the DNA sequence, and the highly dynamic nature of chromatin folding.
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Atomic Spectrometry Update—Atomic Mass Spectrometry and X-Ray Fluorescence Spectrometry
DOI: 10.1039/JA993080261R
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Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.










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