Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

Literature Information

Publication Date 2019-06-25
DOI 10.1039/C9OB01276A
Impact Factor 3.876
Authors

Shota Yanagi, Tomoya Sugai, Takuma Noguchi, Masato Kawakami, Makoto Sasaki, Shinsuke Niwa, Asako Sugimoto, Haruhiko Fuwa


View Original

Abstract

Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.

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Contents list

Front/Back Matter

DOI: 10.1039/C5CP90140E

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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