Solvent-free ruthenium-catalysed triflate coupling as a convenient method for selective azole-o-C–H monoarylation
Literature Information
Publication Date
2019-05-22
DOI
10.1039/C9OB00806C
Impact Factor
3.876
Authors
Taoufik Boubaker, Julien Roger
View Original
Abstract
Metal-catalysed ortho-directed C–H functionalization usually faces selectivity issues in the competition between mono- and disubstitution processes. We report herein the ruthenium-catalysed N-directed C–H monoarylation of arylpyrazoles with a selectivity of up to 96% or that generally reaches values above 80%. This selectivity is an effect of solvent-free conditions associated with sulfonate reagents, in the absence of frequently used acidic additives.
Related Literature
Activation of carbonyl bonds by quaternary ammoniums and a (Na+:crown-ether) complex: investigation of the ring-opening polymerization of cyclic esters
Anne Milet, Frédéric Peruch, Brigitte Bibal
2013-04-03
Paper
DOI: 10.1039/C3PY00304C
Continuous production of iron oxide nanoparticles via fast and economical high temperature synthesis
Maximilian O. Besenhard, Alec P. LaGrow, Simone Famiani, Martina Pucciarelli, Paola Lettieri, Asterios Gavriilidis
2020-07-06
Paper
DOI: 10.1039/D0RE00078G
Azolium hydrogen carbonates and azolium carboxylates as organic pre-catalysts for N-heterocyclic carbene-catalysed group transfer and ring-opening polymerisations
2013-01-25
Paper
DOI: 10.1039/C2PY20915B
Protecting-group-free synthesis of chain-end multifunctional polymers by combining ATRP with thiol–epoxy ‘click’ chemistry
Ikhlas Gadwal, Anzar Khan
2013-03-07
Communication
DOI: 10.1039/C3PY00136A
Thermo-responsive “hairy-rod” polypeptides for smart antitumor drug delivery
Jianxun Ding, Di Li, Chunsheng Xiao, Xiuli Zhuang, Xuesi Chen
2013-03-14
Paper
DOI: 10.1039/C3PY00144J
Well-defined graft copolymers of tert-butyldimethylsilyl methacrylate and poly(dimethylsiloxane) macromonomers synthesized by RAFT polymerization
Marlène Lejars, André Margaillan, Christine Bressy
2013-03-15
Paper
DOI: 10.1039/C3PY00196B
Synthesis and characterization of fluorinated polyionomers. Part I: polyperfluoro-sulfonylethoxy propylene vinyl ether sulfonimides containing aryl sulfonic acids
Anna M. Flach, Frederick E. Johnson, Israel Cabasso
2013-04-05
Paper
DOI: 10.1039/C3PY00315A
Synthesis, photophysical and photovoltaic properties of a new class of two-dimensional conjugated polymers containing donor–acceptor chromophores as pendant groups
Yu-Ying Lai, Yen-Ju Cheng, Chiu-Hsiang Chen, Sheng-Wen Cheng, Fong-Yi Cao, Chain-Shu Hsu
2013-03-18
Paper
DOI: 10.1039/C3PY00168G
UV- and NIR-responsive polymeric nanomedicines for on-demand drug delivery
Gang Liu, Wei Liu, Chang-Ming Dong
2013-01-11
Review Article
DOI: 10.1039/C3PY21121E
Fully bio-based poly(l-lactide)-b-poly(ricinoleic acid)-b-poly(l-lactide) triblock copolyesters: investigation of solid-state morphology and thermo-mechanical properties
Benoit Gadenne, Carine Alfos
2013-03-21
Paper
DOI: 10.1039/C3PY00300K
You might also like
Compound Q&A
What is 1-(2,4,6-Trifluorophenyl)ethanol (CAS: 1250113-83-7)?
1-(2,4,6-Trifluorophenyl)ethanol is an organic compound with the CAS number 1250...
1250113-83-71-(2,4,6-Trifluoroph...
Compound Q&A
Is 1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) safe?
1-(2,4-Dimethoxybenzyl)-4-(hydroxymethyl)-2-pyrrolidinone (CAS: 919111-34-5) is ...
919111-34-51-(2,4-Dimethoxybenz...
Compound Q&A
What are the physical and chemical properties of (7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one (CAS: 51419-51-3)?
(7S,15R)-6β,15-Diacetoxy-7α,20-epoxy-7-hydroxykaura-2,16-dien-1-one is a crystal...
51419-51-3(7S,15R)-6β,15-Diace...
Compound Q&A
What regulatory guidelines apply to rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3618-04-0)?
The compound rac-ethyl (1r,4r)-4-hydroxycyclohexane-1-carboxylate, trans (CAS: 3...
3618-04-0rac-ethyl (1r,4r)-4-...
Compound Q&A
What is the market or research trend for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3)?
The market for 2-(2,4-Difluorophenoxy)-3-nitropyridine (CAS: 175135-62-3) is cur...
175135-62-32-(2,4-Difluoropheno...
Compound Q&A
What are the main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9)?
The main uses of 6-Diazo-5-oxo-L-norleucine (CAS: 157-03-9) include research in ...
157-03-96-Diazo-5-oxo-L-norl...
Compound Q&A
What precautions should be taken when handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5)?
When handling 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS: 173308-19-5), i...
173308-19-52-Aminoethyl-mono-am...
Compound Q&A
How is 5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) typically synthesized?
5-Methylimidazo[1,2-a]pyridine-3-carbaldehyde (CAS: 178488-37-4) can be synthesi...
178488-37-45-Methylimidazo[1,2-...
Compound Q&A
Are there alternatives to 2,4,6-Trihydroxyisophthalaldehyde (CAS: 4396-13-8) in synthesis?
There are alternative reagents that can be used in the synthesis of 2,4,6-Trihyd...
4396-13-82,4,6-Trihydroxyisop...
Compound Q&A
What is (2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid (CAS: 179461-52-0)?
(2Z)-3-(5-Fluoro-1H-indol-3-yl)-2-sulfanylacrylic acid is a chemical compound wi...
179461-52-0(2Z)-3-(5-Fluoro-1H-...
Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.