![9-Ethyl-3-{(E)-[ethyl(2-methylphenyl)hydrazono]methyl}-9H-carbazole structure](https://static.chemtradehub.com/structs/127/1274948-12-7-301f.webp "9-Ethyl-3-{(E)-[ethyl(2-methylphenyl)hydrazono]methyl}-9H-carbazole structure")
9-Ethyl-3-{(E)-[ethyl(2-methylphenyl)hydrazono]methyl}-9H-carbazole
CAS Number:
1274948-12-7
Molecular Formula:
C24H25N3
Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides
Literature Information
Publication Date
2018-06-18
DOI
10.1039/C8OB01229F
Impact Factor
3.876
Authors
Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu
View Original
Abstract
A convenient microwave-assisted method for the synthesis of isoxazoline-functionalized isoquinolines via the n-Bu4NI (TBAI) catalyzed radical cascade cyclization of vinyl isocyanides with β,γ-unsaturated ketoximes has been described. The methodology presented here achieves a wide substrate scope and good to excellent yields. A radical mechanism is proposed, which is supported by the intermolecular competing kinetic isotope effect (KIE) experiment and the radical trapping experiment.
Related Literature
Bi(OTf)3-promoted cascade annulation of hydroxy-pyranones and unsaturated γ-ketoesters for the construction of polycyclic bridged pyrano-furopyranones
2023-12-20
Communication
DOI: 10.1039/D3OB01862H
Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines
Yifei Qu, Xiaojia Cai, Yuzhuang Guan, Jiamin Tan, Zhangping Cai, Minyun Liu, Yasi Huang, Jinhui Hu, Wen-Hua Chen, Jia-Qiang Wu
2023-11-24
Paper
DOI: 10.1039/D3OB01735D
Efficient amidation of weak amines: synthesis, chiral separation by SFC, and antimicrobial activity of N-(9,10-dioxo-9,10-dihydroanthracen-1-yl) carboxamide
A. Zahir Hussain, Andivelu Ilangovan
2023-12-06
Paper
DOI: 10.1039/D3OB01774E
TADDOL-based P,S-bidentate phosphoramidite ligands in palladium-catalyzed asymmetric allylic substitution
Konstantin N. Gavrilov, Ilya V. Chuchelkin, Ilya D. Firsin, Valeria M. Trunina, Vladislav K. Gavrilov, Sergey V. Zheglov, Denis A. Fedorov, Victor A. Tafeenko, Ilya A. Zamilatskov
2023-12-13
Paper
DOI: 10.1039/D3OB01891A
Pd-catalyzed oxa-[4 + n] dipolar cycloaddition using 1,4-O/C dipole synthons for the synthesis of O-heterocycles
Ho-Jun Cho, Ju Hyun Kim
2023-11-20
Review Article
DOI: 10.1039/D3OB01619F
A novel synthetic method for backbone-cyclized polypeptide POL7080 with the help of hydrophobic-support materials
Xiaotong Gu, Weijin Chen, Ting Guo, Xiaohong Chang, Shenyan Zhang, Bingfang Bai, Shutao Ma
2023-12-04
Paper
DOI: 10.1039/D3OB01670F
Cu-catalyzed convenient synthesis of 2-trifluoromethyl benzimidazoles via cyclization of o-phenylenediamines with hexafluoroacetylacetone
Xiao-Yu Zhou, Hai-Long Liu, Sheng Zhang, Ming Bao
2023-11-17
Communication
DOI: 10.1039/D3OB01702H
Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes
Sam Forshaw, Jeremy S. Parker, Neelam Tiwari, Samson M. Oladeji, Andrew C. Stevens, Jami Reber, Guy J. Clarkson, Mohan K. Balasubramanian, Martin Wills
2023-12-13
Paper
DOI: 10.1039/D3OB01712E
Visible light-mediated synthesis of quinazolinones from benzyl bromides and 2-aminobenzamides without using any photocatalyst or additive
Sheng Huang, Liang Jin, Yufeng Liu, Guoping Yang, Aixin Wang, Zhanggao Le, Guofang Jiang, Zongbo Xie
2023-12-20
Paper
DOI: 10.1039/D3OB01491F
You might also like
Compound Q&A
What regulatory guidelines apply to 4-Amino-3-bromophenol (CAS: 74440-80-5)?
4-Amino-3-bromophenol (CAS: 74440-80-5) falls under the classification of a haza...
74440-80-54-Amino-3-bromopheno...
Compound Q&A
How should (17beta)-3-Oxoestr-4-en-17-yl acetate (CAS: 1425-10-1) be stored?
(17beta)-3-Oxoestr-4-en-17-yl acetate should be stored in a cool, dry place away...
1425-10-1(17beta)-3-Oxoestr-4...
Compound Q&A
What are the physical and chemical properties of 2-[(2,2-Diethoxyethyl)disulfanyl]-1,1-diethoxyethane (CAS: 76505-71-0)?
2-[(2,2-Diethoxyethyl)disulfanyl]-1,1-diethoxyethane (CAS: 76505-71-0) is a colo...
76505-71-02-[(2,2-Diethoxyethy...
Compound Q&A
What is the market or research trend for 1-(β-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridin-4-amine?
The market and research for 1-(β-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridin-4-ami...
6736-58-91-(beta-D-Ribofurano...
Compound Q&A
How should waste containing Conjugated Estrogen (CAS: 12126-59-9) be handled?
Waste containing Conjugated Estrogen (CAS: 12126-59-9) should be collected and d...
12126-59-9Conjugated Estrogen
Compound Q&A
What is the market or research trend for Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate?
The market for Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate (CAS...
88738-78-7Bis(2,2,2-trifluoroe...
Compound Q&A
Are there alternatives to 3,4'-Di-O-methylellagic acid (CAS: 57499-59-9) in synthesis?
There are several alternatives to 3,4'-Di-O-methylellagic acid (CAS: 57499-59-9)...
57499-59-93,4'-Di-O-methylella...
Compound Q&A
What regulatory guidelines apply to 2-Chloro-N,N-dimethylpyridin-4-amine (CAS: 59047-70-0)?
2-Chloro-N,N-dimethylpyridin-4-amine (CAS: 59047-70-0) is regulated under the Gl...
59047-70-02-Chloro-N,N-dimethy...
Compound Q&A
What is cerium(3+);oxygen(2-);vanadium(5+) (CAS: 13597-19-8)?
Cerium(3+);oxygen(2-);vanadium(5+) (CAS: 13597-19-8) is a complex inorganic comp...
13597-19-8cerium(3+);oxygen(2-...
Compound Q&A
Is 7-Chloro-1-iodoisoquinoline (CAS: 1203579-27-4) safe?
7-Chloro-1-iodoisoquinoline (CAS: 1203579-27-4) is generally considered safe whe...
1203579-27-47-Chloro-1-iodoisoqu...
Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
![4-[(2-Fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide structure](https://static.chemtradehub.com/structs/104/1041852-85-0-fb1c.webp "4-[(2-Fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide structure")
4-[(2-Fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-3-cinnolinecarboxamide
CAS Number:
1041852-85-0
Molecular Formula:
C23H27FN6O3
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.