Unprecedented synthesis of 1,2,3-triazolo-cinnolinone via Sonogashira coupling and intramolecular cyclization
Literature Information
Dharmendra Kumar Tiwari, Balasubramanian Sridhar
An unprecedented copper mediated one-pot sequential synthesis of 1,2,3-triazolo cinnolinone derivatives from 2-halo-phenyl triazoles and terminal alkynes has been reported. Under the optimized reaction conditions, a broad range of substituted triazoles and alkynes were found to participate in this transformation, thus affording unknown 1,2,3-triazolo cinnolinone derivatives in moderate to excellent yields. This method proceeds through sequential C–C coupling followed by an annulation cascade sequence in the same vessel under atmospheric air as the sole oxidant, thus representing a simple, efficient and atom economical approach for the synthesis of aza-cinnolinones.
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.











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