An efficient iodine pentoxide-triggered iodocarbocyclization for the synthesis of iodooxindoles in water
Literature Information
Ming-Zhong Zhang, Xin Wang, Ming-Ying Gong, Lin Chen, Wen-Bing Shi, Shu-Hua He, Yong Jiang, Tieqiao Chen
An efficient iodocarbocyclization of alkenes for the synthesis of iodooxindoles has been developed. This reaction proceeds in a chemoselective manner and shows excellent tolerance of various functional groups, including a chemosensitive hydroxymethyl group. Nonmetal inorganic iodine pentoxide was used as both the oxidant and iodine source, making this protocol very practical. On the basis of experimental observations, a plausible electrophilic reaction mechanism was proposed.
Related Literature
Government of Bengal. Annual Report of the Chemical Examiner for 1939
DOI: 10.1039/AN941660202A
International Union of Chemistry. Fifth Report of the Committee on Atoms
DOI: 10.1039/AN940650568B
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.










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