![4-{2-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazino}benzoic acid structure](https://static.chemtradehub.com/structs/214/214475-53-3-bf36.webp "4-{2-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazino}benzoic acid structure")
4-{2-[(9H-Fluoren-9-ylmethoxy)carbonyl]hydrazino}benzoic acid
CAS Number:
214475-53-3
Molecular Formula:
C22H18N2O4
A highly efficient dual-diazonium reagent for protein crosslinking and construction of a virus-based gel
Literature Information
Publication Date
2018-04-04
DOI
10.1039/C8OB00169C
Impact Factor
3.876
Authors
Dejun Ma, Changyu Zhang, Yuwen Men, Hongyan Sun, Lu-Yuan Li, Long Yi, Zhen Xi
View Original
Abstract
A new bench-stable reagent with double diazonium sites was designed and synthesized for protein crosslinking. Based on the highly efficient diazonium-Tyr coupling reaction, a direct mixture of the reagent and tobacco mosaic virus led to the formation of a new hydrogel, which could be degraded by chemicals and could be used to encapsulate small molecules for sustained release. Because plant viruses exhibit many chemical characteristics like protein labelling and nucleic acid packaging, the virus-based hydrogel will have large chemical space for further functionalization. Besides, this dual-diazonium reagent should be a generally useful crosslinker for chemical biology and biomaterials.
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
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