2-Amino-2-(4-(pyridin-2-YL)phenyl)acetic acid hydrochloride
CAS Number:
1135818-89-1
Molecular Formula:
C13H13ClN2O2
Bifunctional catalysis in the stereocontrolled synthesis of tetrahydro-1,2-oxazines
Literature Information
Publication Date
2017-12-08
DOI
10.1039/C7OB02894F
Impact Factor
3.876
Authors
Marek Moczulski, Piotr Drelich, Łukasz Albrecht
View Original
Abstract
This study demonstrates that the annulation of a tetrahydro-1,2-oxazine ring can be realized via bifunctional catalysis, employing nitroolefins and a recently introduced group of aminooxylating reagents as starting materials. The developed cascade reactivity proceeds in a sequence aza-Michael–Michael reaction. The target products, bearing three contiguous stereocenters, have been obtained with high yields (up to 97%) and excellent stereocontrol (>20 : 1 dr, up to 99.5 : 0.5 er).
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
amine structure](https://static.chemtradehub.com/structs/629/62924-61-2-0728.webp "[(2-chlorophenyl)methyl](ethyl)amine structure")
methyl 6-bromo-3-formyl-1H-indole-4-carboxylate
CAS Number:
1353636-63-1
Molecular Formula:
C11H8BrNO3
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