Highly efficient asymmetric construction of novel indolines and tetrahydroquinoline derivatives via aza-Barbier/C–N coupling reaction

Literature Information

Publication Date 2017-12-04
DOI 10.1039/C7OB02891A
Impact Factor 3.876
Authors

Bin-Hua Yuan, Wen-Jie Liu


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Abstract

Highly stereoselective syntheses of chiral indolines and tetrahydroquinolines are achieved by combining the asymmetric Zn-mediated allylation of chiral N-tert-butanesulfinyl imines with efficient intramolecular C–N cross-coupling. Herein, the advantages of such a synthetic strategy are illustrated by the synthesis of indolines and tetrahydroquinolines with quaternary stereocenters and multi-substituted 1-oxo-1,2,3,4-tetrahydroisoquinolines.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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