DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

Literature Information

Publication Date 2017-12-12
DOI 10.1039/C7OB02860A
Impact Factor 3.876
Authors

Akkharaphong Thupyai, Chaleena Pimpasri, Sirilata Yotphan


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Abstract

A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(I) acetate, the C–S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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