Bioluminescent probe for detecting endogenous hypochlorite in living mice

Literature Information

Publication Date 2017-12-19
DOI 10.1039/C7OB02842C
Impact Factor 3.876
Authors

Chunchao Tang, Yuqi Gao, Tingting Liu, Yuxing Lin, Xiaomeng Zhang, Chaochao Zhang, Xiang Li, Tianchao Zhang, Lupei Du


View Original

Abstract

As a kind of biologically important reactive oxygen species (ROS), hypochlorite (ClO−) plays a crucial role in many physiological processes. As such, endogenous ClO− is a powerful antibacterial agent during pathogen invasion. Nonetheless, excessive endogenous ClO− could pose a health threat to mammalian animals including humans. However, the detection of endogenous ClO− by bioluminescence probes in vivo remains a considerable challenge. Herein, based on a caged strategy, we developed a turn-on bioluminescent probe 1 for the highly selective detection of ClO−in vitro and imaging endogenous ClO− in a mouse inflammation model. We anticipate that such a probe could help us understand the role of endogenous ClO− in a variety of physiological and pathological processes.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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