Synthesis of spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles via divergent, thermally induced tandem cyclization/migration of alkyne-tethered diazo compounds

Literature Information

Publication Date 2017-12-06
DOI 10.1039/C7OB02802D
Impact Factor 3.876
Authors

Cheng Zhang, Shanliang Dong, Yang Zheng, Ciwang He, Jiaolong Chen, Jingsen Zhen, Lihua Qiu, Xinfang Xu


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Abstract

A thermally induced, substrate-dependent reaction of alkynyl diazo compounds has been developed. This transformation produces spiro-4H-pyrazole-oxindoles and fused 1H-pyrazoles in good to high yields from the corresponding alpha-cyano and alpha-sulfonyl diazo compounds. The salient features of this reaction include excellent chemoselectivity and atom-economy, mild reaction conditions, simple purification and potential for large scale production.

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Organic & Biomolecular Chemistry
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