A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols

Literature Information

Publication Date 2017-12-07
DOI 10.1039/C7OB02599H
Impact Factor 3.876
Authors

Jianqiao Zhou, Hexin Xie


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Abstract

Reported herein is a chiral Brønsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile access to a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. Furthermore, a significant effect of an N-protecting group was observed in this asymmetric process.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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