Rhodium-catalyzed benzoisothiazole synthesis by tandem annulation reactions of sulfoximines and activated olefins
Literature Information
Yang Li, Lin Dong
Rhodium(III)-catalyzed N-directed ortho C–H activation reactions have been developed for the synthesis of unique heterocyclic benzoisothiazoles. Herein, this novel tandem annulation approach can efficiently construct benzoisothiazole compounds from free NH-sulfoximines and alkenes via C–H activation, olefination and subsequent intramolecular aza-Michael cyclization.
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.














