Rhodium-catalyzed benzoisothiazole synthesis by tandem annulation reactions of sulfoximines and activated olefins

Literature Information

Publication Date 2017-11-16
DOI 10.1039/C7OB02586F
Impact Factor 3.876
Authors

Yang Li, Lin Dong


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Abstract

Rhodium(III)-catalyzed N-directed ortho C–H activation reactions have been developed for the synthesis of unique heterocyclic benzoisothiazoles. Herein, this novel tandem annulation approach can efficiently construct benzoisothiazole compounds from free NH-sulfoximines and alkenes via C–H activation, olefination and subsequent intramolecular aza-Michael cyclization.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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