Nanoprodrug of retinoic acid-modified paclitaxel
Literature Information
Publication Date
2017-10-27
DOI
10.1039/C7OB02553J
Impact Factor
3.876
Authors
Zijun Zhou, Jingzhe Yan, Xin Wang, Zhigang Xie
View Original
Abstract
All-trans-retinoic acid (RA) is a non-toxic physiological metabolite of vitamin A. A paclitaxel (PTX) prodrug (RA-PTX) with high PTX content of 75% was synthesized via an easy condensation reaction. RA-PTX nanoparticles (RA-PTX NPs) were prepared through a nanoprecipitation method which increased the water solubility of PTX. RA-PTX NPs were spherical in shape and exhibited favorable structural stability in both water and the physiological environment. RA-PTX NPs possessed effective cellular uptake as revealed by confocal laser scanning microscopy and exerted potent cytotoxicity. These results highlight the potential of nanomedicines from PTX prodrugs for increasing the drug loading and water solubility of PTX.
Related Literature
Soft nanotubes from amphiphilic ABA triblock macromonomers
Julie Grumelard, Andreas Taubert, Wolfgang Meier
2004-05-25
Communication
DOI: 10.1039/B405671J
Synthesis of monodisperse iron oxidenanocrystals by thermal decomposition of iron carboxylate salts
William W. Yu, Joshua C. Falkner, Cafer T. Yavuz, Vicki L. Colvin
2004-09-02
Communication
DOI: 10.1039/B409601K
Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis
Russell J. Cox, Frank Glod, Deirdre Hurley, Colin M. Lazarus, Thomas. P. Nicholson, Brian A. M. Rudd, Thomas J. Simpson, Barrie Wilkinson, Ying Zhang
2004-09-24
Communication
DOI: 10.1039/B411973H
Transformation of highly ordered large pore silica mesophases (Fm3m, Im3m and p6mm) in a ternary triblock copolymer–butanol–water system
Freddy Kleitz, Leonid A. Solovyov, Gopinathan M. Anilkumar, Shin Hei Choi, Ryong Ryoo
2004-06-02
Communication
DOI: 10.1039/B403903C
Synthesis and properties of rhenium tricarbonyl complex bearing N-fused tetraphenylporphyrin ligand
Motoki Toganoh, Tomoya Ishizuka
2004-09-20
Communication
DOI: 10.1039/B406234E
Mechanistic and stereochemical aspects of the asymmetric cyclocarbonylation of 1,6-enynes with rhodium catalysts
Thomas M. Schmid, Giambattista Consiglio
2004-09-06
Communication
DOI: 10.1039/B407843H
Synthesis and study of a new diamidodipyrromethane macrocycle. An anion receptor with a high sulfate-to-nitrate binding selectivity
Jonathan L. Sessler, G. Dan Pantos, Yuri A. Ustynyuk
2004-05-03
Communication
DOI: 10.1039/B403665D
Kinetics of chalconeoxidation by peroxide anion catalysed by poly-l-leucine
Giacomo Carrea, Stefano Colonna, Alastair D. Meek, Gianluca Ottolina, Stanley M. Roberts
2004-05-17
Communication
DOI: 10.1039/B401497A
Nano-complex formation of cyclodextrin and azobenzene using supercritical carbon dioxide
Min Wu, Yoshiaki Yuguchi, Takako Kumagai, Takashi Endo, Takahiro Hirotsu
2004-05-10
Communication
DOI: 10.1039/B400289J
Fe–Ce–ZSM-5 a new catalyst of outstanding properties in the selective catalytic reduction of NO with NH3
G. Carja, G. Delahay, C. Signorile, B. Coq
2004-05-17
Communication
DOI: 10.1039/B402660H
You might also like
Compound Q&A
What precautions should be taken when handling 2-Chloro-1,2-bis(4-methylphenyl)ethanone (CAS: 71193-32-3)?
When handling 2-Chloro-1,2-bis(4-methylphenyl)ethanone (CAS: 71193-32-3), it is ...
71193-32-32-Chloro-1,2-bis(4-m...
Compound Q&A
What industries use 4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonyl chloride (CAS: 224789-26-8)?
4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl...
224789-26-84-Ethoxy-3-(5-methyl...
Compound Q&A
How should Methyl 3-Oxo-4-Androsten-17-Carboxylate (CAS: 2681-55-2) be stored?
Methyl 3-Oxo-4-Androsten-17-Carboxylate (CAS: 2681-55-2) should be stored in a c...
2681-55-2Methyl 3-Oxo-4-Andro...
Compound Q&A
What are the main uses of (R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid (CAS: 909725-61-7)?
(R)-3-Amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid is primarily used i...
909725-61-7(R)-3-Amino-4-(3-hex...
Compound Q&A
What regulatory guidelines apply to 2-Methyl-2-propanyl 3-amino-3-carbamoyl-1-azetidinecarboxylate (CAS: 1254120-14-3)?
2-Methyl-2-propanyl 3-amino-3-carbamoyl-1-azetidinecarboxylate (CAS: 1254120-14-...
1254120-14-32-Methyl-2-propanyl ...
Compound Q&A
Are there alternatives to (E)-4-(tert-Butoxy)-4-oxobut-2-enoic acid (CAS: 135355-96-3) in synthesis?
There are alternative reagents that can be used in synthesis instead of (E)-4-(t...
135355-96-3(E)-4-(tert-Butoxy)-...
Compound Q&A
What are the physical and chemical properties of [2-(3-Chlorophenyl)-1,3-thiazol-4-yl]methanol (CAS: 121202-20-8)?
[2-(3-Chlorophenyl)-1,3-thiazol-4-yl]methanol (CAS: 121202-20-8) is a crystallin...
121202-20-8[2-(3-Chlorophenyl)-...
Compound Q&A
What is the market or research trend for Methyl (2S)-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]{[(4-methylphenyl)sulfonyl]oxy}acetate (CAS: 166249-17-8)?
The market and research trends for Methyl (2S)-[(4S)-2,2-dimethyl-1,3-dioxolan-4...
166249-17-8Methyl (2S)-[(4S)-2,...
Compound Q&A
What is the market or research trend for 1-Bromo-2-isocyanatoethane (CAS: 42865-19-0)?
The market for 1-Bromo-2-isocyanatoethane (CAS: 42865-19-0) is driven by its use...
42865-19-01-Bromo-2-isocyanato...
Compound Q&A
What are the main uses of 4-Nitro-D-phenylalanine hydrochloride (CAS: 147065-06-3)?
4-Nitro-D-phenylalanine hydrochloride (CAS: 147065-06-3) is primarily used in re...
147065-06-34-Nitro-D-phenylalan...
Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.