A “turn-off” red-emitting fluorophore for nanomolar detection of heparin
Literature Information
Palash Jana, Mithun Radhakrishna, Saumyakanti Khatua, Sriram Kanvah
A simple fluorophore bearing a diethylaminocoumarin donor and a pyridinium acceptor was synthesized and utilized for the ultra-sensitive detection of heparin. The synthesized dicationic push–pull coumarin derivative emits strongly in the red-region (665 nm) and detects nanomolar concentrations (14.8 nM to 148 nM) of heparin in HEPES buffer and FBS serum solutions. The dication exhibits excellent fluorescence selectivity and sensitivity towards heparin over its analogues such as chondroitin 4-sulfate (CS), hyaluronic acid (HA) and dextran. This fluorescence assay is a convenient, sensitive method for monitoring heparin levels in biological samples. These findings were confirmed using coarse-grained Monte Carlo simulations, which provide us with a rationale for the selective binding of heparin.
Recommended Journals
Related Literature
What is special about silicon in functionalised organic semiconductors?
Micai Benford, Yang Song, Sean R. Parkin
DOI: 10.1039/D1MA00447F
Non-matrix matched calibration of major and minor concentrations of Zn and Cu in brass, aluminium and silicate glass using NIR femtosecond laser ablation inductively coupled plasma mass spectrometry
Qunzhou Bian, Carmen C. Garcia, Joachim Koch, Kay Niemax
DOI: 10.1039/B513690C
Performance and application of carbon-based electrocatalysts in direct methanol fuel cell
Pritam Deb
DOI: 10.1039/D1MA00503K
Simultaneous improvement of kinetics and thermodynamics based on SrF2 and SrF2@Gr additives on hydrogen sorption in MgH2
Vivek Shukla, Ashish Bhatnagar, Satish K. Verma, Anant P. Pandey, Alok K. Vishwakarma, Pankaj Srivastava, T. P. Yadav, O. N. Srivastava
DOI: 10.1039/D1MA00012H
Selective hydration of dihydromyrcene in ionic liquids
Paul N. Davey, Martyn J. Earle, Jennifer T. Hamill, Suhas P. Katdare, David W. Rooney, Kenneth R. Seddon
DOI: 10.1039/B915131A
The effect of the ionic liquid anion in the pretreatment of pine wood chips
Jason P. Hallett, Tom Welton
DOI: 10.1039/B918787A
Malleable and recyclable imide–imine hybrid thermosets: influence of imide structure on material property
Xiran Shen, Yunlong Ma, Shichang Luo, Rao Tao, Dan An, Xinlei Wei, Yinghua Jin, Li Qiu, Wei Zhang
DOI: 10.1039/D1MA00311A
Continuous flow synthesis of functionalized silver nanoparticles using bifunctional biosurfactants
D. V. Ravi Kumar, Manasi Kasture, A. A. Prabhune, C. V. Ramana, B. L. V. Prasad, A. A. Kulkarni
DOI: 10.1039/B919550E
You might also like
What precautions should be taken when handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3)?
When handling 4-Methyl-6-(trifluoromethyl)quinoline (CAS: 40716-16-3), safety go...
What is 4-(3,5-Difluorophenyl)aniline (CAS: 405058-00-6)?
4-(3,5-Difluorophenyl)aniline is an aromatic organic compound with the CAS numbe...
How is 5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid (CAS: 338982-07-3) typically synthesized?
5-{[4-(Trifluoromethyl)phenyl]sulfanyl}-1,2,3-thiadiazole-4-carboxylic acid can ...
What is the market or research trend for 4-Benzylaniline hydrochloride (CAS: 6317-57-3)?
The market for 4-Benzylaniline hydrochloride (CAS: 6317-57-3) is steadily growin...
Is [3-(Diethylsulfamoyl)phenyl]boronic acid (CAS: 871329-58-7) safe?
[3-(Diethylsulfamoyl)phenyl]boronic acid is generally considered safe when handl...
What are the main uses of 3-Bromo-2,5-dimethoxyaniline (CAS: 115929-62-9)?
3-Bromo-2,5-dimethoxyaniline is mainly used in the pharmaceutical and chemical i...
What regulatory guidelines apply to N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7)?
N-Methyl-1-(5-methyl-1H-indol-3-yl)methanamine (CAS: 915922-67-7) is subject to ...
What industries use Carbamic acid, N-[(5S)-5,6-diamino-6-oxohexyl]-, 1,1-dimethylethyl ester (CAS: 24828-96-4)?
This compound is primarily used in the pharmaceutical industry for the synthesis...
How should 2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) be stored?
2-Methyl-2-propanyl [(1S,3R)-3-aminocyclohexyl]carbamate (CAS: 1298101-47-9) sho...
What industries use Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9)?
Ethyl 2-bromo-4,4,4-trifluorobutanoate (CAS: 367-33-9) is utilized in the pharma...
Source Journal
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.














