Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine
Literature Information
Publication Date
2017-08-04
DOI
10.1039/C7AN01099K
Impact Factor
4.616
Authors
Shishi Ma, Qiao-Yu Zhou, Fang-Ya Mu, Zi-Han Chen, Xu-Yin Ding, Min Zhang, Guoyue Shi
View Original
Abstract
A novel and facile ratiometric fluorescence method for evaluating Cu2+ has been developed based on coumarin-labeled single-stranded DNA (C-ssDNA) coupled with the Cu2+-induced oxidation of o-phenylenediamine (OPD). By combining the microdialysis technique, the ratiometric fluorescence method has also been successfully exploited to monitor the cerebral Cu2+ in the rat brain, promising new opportunities for studying the cerebral Cu2+-associated physiological and pathological events.
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Source Journal
Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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N,N-dimethyl(piperidin-4-yl)methanamine hydrochloride
CAS Number:
172281-72-0
Molecular Formula:
C8H20Cl2N2
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