Thiol–ene micropillar array electrospray ionization platform for zeptomole level bioanalysis
Literature Information
Publication Date
2017-06-15
DOI
10.1039/C7AN00544J
Impact Factor
4.616
Authors
K. Lipponen, S. Tähkä, T. Sikanen, V. Jokinen, A. Tatikonda, S. Franssila, R. Kostiainen
View Original
Abstract
A micropillar array electrospray ionization (μPESI) platform fabricated from thiol–enes with 56 individual polyethylene glycol coated μPESI chips for bioanalytical mass spectrometry is introduced. Bioanalysis capability is shown by measurement of a protein, a protein digest and a cell lysate sample. The thiol–ene polyethylene glycol (PEG) coated μPESI chip allows the use of a wide range of aqueous–organic solvent compositions and provides a detection limit at 60 zeptomole level (6 × 10−20 mol) for a peptide standard.
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