Polycarbonate-based biodegradable copolymers for stimuli responsive targeted drug delivery
Literature Information
Mutyala Naidu Ganivada, Pawan Kumar, Pintu Kanjilal, Himadri Dinda, Jayasri Das Sarma, Raja Shunmugam
The need for efficient nanoscale polymeric systems that elegantly target cancer-affected areas in the body has arisen, since drug efficacy is mostly disturbed by nonspecific cell and tissue biodistribution. Motivated by the challenges, we have developed a novel tumour-targeting polymeric nanocarrier using polylactide and polycarbonate as the polymeric backbone. Biotin and doxorubicin are covalently attached to the poylmeric backbone using a combination of ring opening polymerisation and click chemistry. All the monomers and polymers are characterised carefully through standard analytical techniques. The self-assembly behaviour of these copolymers is studied through DLS and FE-SEM analysis. Doxorubicin release from the copolymer backbone is pH-dependent owing to the unique oxime linker. Cell culture studies of the biotin and doxorubicin-conjugated nanocarrier [Bt-(PE-PA-PC)-DRoxm] exhibited higher intracellular doxorubicin accumulation at cancer cells. The newly developed polymeric nanocarrier could open a new avenue for cancer therapy, due to its unique design as well as, most importantly, its biocompatible and biodegradable nature.
Recommended Journals

Russian Journal of Coordination Chemistry

Russian Journal of Bioorganic Chemistry

Journal of Saudi Chemical Society

Crystallography Reports

Saudi Pharmaceutical Journal

Journal of Natural Medicines

Nature Medicine

Current Opinion in Colloid & Interface Science

Russian Journal of Applied Chemistry

Chemistry Education Research and Practice
Related Literature
Effect of the state of distribution of supported Pt nanoparticles on effective Pt utilization in polymer electrolyte fuel cells
Makoto Uchida, Young-Chul Park, Katsuyoshi Kakinuma, Hiroshi Yano, Donald A. Tryk, Takeo Kamino, Hiroyuki Uchida, Masahiro Watanabe
DOI: 10.1039/C3CP51801A
Kinetics of Schottky defect formation and annihilation in single crystal TlBr
Harry L. Tuller, Melanie Kuhn, Guido Ciampi, William Higgins, Kanai S. Shah
DOI: 10.1039/C3CP51043C
An in situXAFS study—the formation mechanism of gold nanoparticles from X-ray-irradiated ionic liquid
DOI: 10.1039/C3CP51743H
Multiphoton photoelectron emission microscopy of single Au nanorods: combined experimental and theoretical study of rod morphology and dielectric environment on localized surface plasmon resonances
Andrej Grubisic, Volker Schweikhard, Thomas A. Baker, David J. Nesbitt
DOI: 10.1039/C3CP44385J
Nuclear spin–spin coupling anisotropy in the van der Waals-bonded 129Xe dimer
Jukka Jokisaari, Juha Vaara
DOI: 10.1039/C3CP50625H
Molecular rheometry: direct determination of viscosity in Lo and Ldlipid phases via fluorescence lifetime imaging
Yilei Wu, Agnieszka Olzyńska, Martin Hof, Gokhan Yahioglu, Duncan R. Casey, Oscar Ces, Jana Humpolíčková, Marina K. Kuimova
DOI: 10.1039/C3CP51953H
Towards systematically improvable models for actinides in condensed phase: the electronic spectrum of uranyl in Cs2UO2Cl4 as a test case
André Severo Pereira Gomes, Christoph R. Jacob, Florent Réal, Lucas Visscher, Valérie Vallet
DOI: 10.1039/C3CP52090K
Ionothermal synthesis of mesoporous SnO2 nanomaterials and their gas sensitivity depending on the reducing ability of toxic gases
Wei Guo, Xiaochuan Duan, Yan Shen, Kezhen Qi, Caiying Wei, Wenjun Zheng
DOI: 10.1039/C3CP51663F
Chromism based on supramolecular H-bonds
Chuanlang Zhan, Xunlei Ding, Shanlin Zhang, Xin Zhang, Huiying Liu, Lili Chen, Yishi Wu, Hongbing Fu, Shenggui He, Yan Huang, Jiannian Yao
DOI: 10.1039/C3CP51268A
You might also like
Are there alternatives to 1-(4-Chlorophenyl)-N-hydroxymethanimine (CAS: 3848-36-0) in synthesis?
When considering alternatives to 1-(4-Chlorophenyl)-N-hydroxymethanimine (CAS: 3...
How should (1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.1~6,9~.0~2,7~]tetracosa-2,5,7,14-tetraen-4-one (CAS: 183202-73-5) be stored?
This compound should be stored in a cool, dry place away from direct sunlight. I...
How is 3-(4-Bromophenyl)-5-(2-fluorophenyl)-1,2,4-oxadiazole (CAS: 419553-16-5) typically synthesized?
3-(4-Bromophenyl)-5-(2-fluorophenyl)-1,2,4-oxadiazole is synthesized through a m...
How is 5-Chloro-2-(4-chlorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]pyrimidine (CAS: 1639220-19-1) typically synthesized?
5-Chloro-2-(4-chlorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]pyrimidine (CAS...
What industries use 2-Chloro-4-(difluoromethoxy)pyridine (CAS: 1206978-15-5)?
2-Chloro-4-(difluoromethoxy)pyridine is used in the pharmaceutical industry for ...
What regulatory guidelines apply to 3-Chloro-6-methylpyridazine (CAS: 1121-79-5)?
3-Chloro-6-methylpyridazine (CAS: 1121-79-5) is classified under the Globally Ha...
Are there alternatives to Methyl 4,5-dimethyl-2-nitrobenzoate in synthesis?
Several alternatives can be used in the synthesis of Methyl 4,5-dimethyl-2-nitro...
Are there alternatives to (2E,2'E)-3,3'-(1,4-Phenylene)bisacrylaldehyde in synthesis?
Alternatives to (2E,2'E)-3,3'-(1,4-Phenylene)bisacrylaldehyde include other acry...
What is 3-Amino-5-chloropyridin-2-ol hydrochloride (CAS: 1261906-29-9)?
3-Amino-5-chloropyridin-2-ol hydrochloride is an organic compound with the CAS n...
What precautions should be taken when handling 6,7-Difluoro-2,3-dihydro-4H-chromen-4-one (CAS: 1092349-93-3)?
When handling 6,7-Difluoro-2,3-dihydro-4H-chromen-4-one, it is essential to wear...
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.




