![Ethyl 2-[(3-bromo-4-pyridinyl)sulfanyl]-2-methylpropanoate structure](https://static.chemtradehub.com/structs/135/1352794-86-5-a8aa.webp "Ethyl 2-[(3-bromo-4-pyridinyl)sulfanyl]-2-methylpropanoate structure")
Ethyl 2-[(3-bromo-4-pyridinyl)sulfanyl]-2-methylpropanoate
CAS Number:
1352794-86-5
Molecular Formula:
C11H14BrNO2S
Chemical profiling of cerebrospinal fluid by multiple reaction monitoring mass spectrometry‡
Literature Information
Publication Date
2016-08-05
DOI
10.1039/C6AN01618A
Impact Factor
4.616
Authors
Christina R. Ferreira, Karen E. Yannell, Brit Mollenhauer, Ryan D. Espy, Fernanda B. Cordeiro, Z. Ouyang, R. G. Cooks
View Original
Abstract
We report an accelerated biomarker discovery workflow and results of sample screening by mass spectrometry based on multiple reaction monitoring (MRM). This methodology shows promising initial results for the currently unsolved challenge of Parkinson's disease (PD) laboratory diagnosis by biomarker screening. Small molecules present in cerebrospinal fluid (CSF) at low parts per million levels are monitored using specific transitions connecting ion pairs. A set of such transitions constitutes a multidimensional chemical profile used to distinguish and characterize different CSF samples using multivariate statistical methods.
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Source Journal
Analyst
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5.6%
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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4-[(2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butanoic acid
CAS Number:
58899-27-7
Molecular Formula:
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