![(1R,5R)-3-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azabicyclo[3.1.0]hexane-1-carboxylic acid structure](https://static.chemtradehub.com/structs/116/1165450-63-4-bfe1.webp "(1R,5R)-3-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azabicyclo[3.1.0]hexane-1-carboxylic acid structure")
(1R,5R)-3-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azabicyclo[3.1.0]hexane-1-carboxylic acid
CAS Number:
1165450-63-4
Molecular Formula:
C11H17NO4
Can saliva testing replace blood measurements for health monitoring? Insights from a correlation study of salivary and whole blood glutathione in humans
Literature Information
Publication Date
2016-06-03
DOI
10.1039/C6AN01139J
Impact Factor
4.616
Authors
Kamonwad Ngamchuea, Christopher Batchelor-McAuley, Philip J. Cowen, Clare Williams, Luís Moreira Gonçalves, Richard G. Compton
View Original
Abstract
The feasibility of using saliva samples as diagnostic for health status is assessed. Although blood is regularly used for this purpose, an alternative non-invasive route which yields equivalent clinical information is desirable. The non-invasive saliva testing is validated by comparing its result to that of blood examination. In this investigation, we used glutathione as a paradigmatic example of a biomarker and diagnostic auxiliary. Correlation between the levels of total unbound glutathione, reduced and oxidized, in saliva and whole blood samples from healthy individuals is evaluated. Both salivary and blood glutathione were measured using an enzymatic kinetic assay which was improved to eliminate measurement errors arising from the variation in the enzyme activity from different batches.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
![8-Bromo-6-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine structure](https://static.chemtradehub.com/structs/125/1257705-51-3-9f4a.webp "8-Bromo-6-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine structure")
8-Bromo-6-fluoro[1,2,4]triazolo[1,5-a]pyridin-2-amine
CAS Number:
1257705-51-3
Molecular Formula:
C6H4BrFN4
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