A pH-sensitive and biodegradable supramolecular hydrogel constructed from a PEGylated polyphosphoester-doxorubicin prodrug and α-cyclodextrin
Literature Information
Publication Date
2015-06-03
DOI
10.1039/C5PY00620A
Impact Factor
5.582
Authors
Fei Li, Jinlin He, Mingzu Zhang, Peihong Ni
View Original
Abstract
An acid-labile and PEGylated polyphosphoester-doxorubicin prodrug (PBYP-g-PEG-g-DOX) was prepared via a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry. The resulting multifunctional prodrug was then used to interact with α-cyclodextrin (α-CD) to fabricate a novel supramolecular hydrogel based on inclusion complexation.
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Polymer Chemistry
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