![2-Methyl-2-propanyl 4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate structure](https://static.chemtradehub.com/structs/131/1312456-05-5-9a15.webp "2-Methyl-2-propanyl 4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate structure")
2-Methyl-2-propanyl 4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate
CAS Number:
1312456-05-5
Molecular Formula:
C12H20N2O3
Graphene oxide complex as a pH-sensitive antitumor drug
Literature Information
Publication Date
2015-01-29
DOI
10.1039/C5PY00047E
Impact Factor
5.582
Authors
Rumei Cheng, Ruitao Zou, Shengju Ou, Rui Guo, Ruiying Yan, Haiyan Shi, Shanshan Yu, Xiaojian Li, Yexu Bu, Mimi Lin, Yong Liu
View Original
Abstract
A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
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