Graphene oxide complex as a pH-sensitive antitumor drug
Literature Information
Rumei Cheng, Ruitao Zou, Shengju Ou, Rui Guo, Ruiying Yan, Haiyan Shi, Shanshan Yu, Xiaojian Li, Yexu Bu, Mimi Lin, Yong Liu
A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.
Recommended Journals

Biocatalysis and Biotransformation

Critical Reviews in Solid State and Materials Sciences

Acta Metallurgica Sinica-English Letters

Journal of the Indian Institute of Science

NDT & E International

Heteroatom Chemistry

Herald of the Russian Academy of Sciences

Cellulose

Main Group Chemistry

Atomization and Sprays
Related Literature
Photocatalytic printing of inorganic nanopatterns via poly(styrene-block-carbosilane) copolymer thin films on titania substrates
Juan Peng, Alejandra Garcia Marcos, Seong-Jun Jeong, Holger Frey, Dong Ha Kim
DOI: 10.1039/B816398G
Nitrogen-doped titania nanosheets towards visible light response
Lianzhou Wang, Chenghua Sun, Zhigang Chen, Xiaoxia Yan, Lina Cheng, Hui-Ming Cheng, Gao Qing (Max) Lu
DOI: 10.1039/B820483G
Shape auxiliary approach for carboxylate-functionalized gold nanocrystals
Daeha Seo, Choong Il Yoo, Bong Hyun Chung, Im Sik Chung, Hyunjoon Song
DOI: 10.1039/B820220F
Amphiphilic block copolymers based on cyclodextrinhost–guest complexes via RAFT-polymerization in aqueous solution
Heike S. Köllisch, Christopher Barner-Kowollik, Helmut Ritter
DOI: 10.1039/B818897A
Directed covalent assembly of rigid organic nanodisks using self-assembled temporary scaffolds‡
Samuel Tekobo, Eugene Pinkhassik
DOI: 10.1039/B817598E
The generation and trapping of enantiopure bromonium ions
D. Christopher Braddock, Stephen A. Hermitage, Lilian Kwok, Rebecca Pouwer, Joanna M. Redmond, Andrew J. P. White
DOI: 10.1039/B816914D
Electrochemical preparation of Pd nanorods with high-index facets
Na Tian, Zhi-You Zhou, Shi-Gang Sun
DOI: 10.1039/B819751B
Electrogenerated chemiluminescence of a bis-cyclometalated alkynylgold(iii) complex with irreversible oxidation using tri-n-propylamine as co-reactant
Zuofeng Chen, Keith Man-Chung Wong, Vonika Ka-Man Au, Yanbing Zu, Vivian Wing-Wah Yam
DOI: 10.1039/B820400D
You might also like
What are the main uses of (5-Sulfamoyl-3-pyridinyl)boronic acid (CAS: 951233-61-7)?
(5-Sulfamoyl-3-pyridinyl)boronic acid is primarily used in chemical synthesis, p...
How is Benzyl 2-methyl-2-(methylsulfonyl)-4-pentenoate (CAS: 1942858-50-5) typically synthesized?
Benzyl 2-methyl-2-(methylsulfonyl)-4-pentenoate is typically synthesized via est...
What precautions should be taken when handling 8-Fluoroquinolin-6-ol (CAS: 209353-22-0)?
When handling 8-Fluoroquinolin-6-ol (CAS: 209353-22-0), it is important to use p...
What are the physical and chemical properties of 1,3-Dibromo-5-(2-methyl-2-propanyl)benzene (CAS: 129316-09-2)?
1,3-Dibromo-5-(2-methyl-2-propanyl)benzene (CAS: 129316-09-2) is a crystalline c...
What industries use Ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate (CAS: 174726-87-5)?
Ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carbox...
What precautions should be taken when handling Delta-7-Avenasterol (CAS: 23290-26-8)?
When handling Delta-7-Avenasterol (CAS: 23290-26-8), it is important to wear app...
What precautions should be taken when handling N-({(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide (CAS: 872992-20-6)?
Proper handling involves the use of personal protective equipment such as gloves...
What precautions should be taken when handling 2-Methyl-2-proanyl 4-[(2-aminophenyl)amino]-1-piperidinecarboxylate (CAS: 79099-00-6)?
When handling 2-Methyl-2-proanyl 4-[(2-aminophenyl)amino]-1-piperidinecarboxylat...
What is N-Methyl-4-chlorobenzylamine hydrochloride (CAS: 65542-24-7)?
N-Methyl-4-chlorobenzylamine hydrochloride (CAS: 65542-24-7) is a organic compou...
Is [2-(Dodecyloxy)ethoxy]acetic acid (CAS: 27306-90-7) safe?
[2-(Dodecyloxy)ethoxy]acetic acid (CAS: 27306-90-7) is generally considered safe...
Source Journal
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
![2-Methyl-2-propanyl 4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate structure 2-Methyl-2-propanyl 4-oxo-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate structure](https://static.chemtradehub.com/structs/131/1312456-05-5-9a15.webp)



![(4-Methyl-1H-benzo[d]imidazol-2-yl)methanamine structure (4-Methyl-1H-benzo[d]imidazol-2-yl)methanamine structure](https://static.chemtradehub.com/structs/933/933756-31-1-7b0b.webp)