Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

Literature Information

Publication Date 2014-04-15
DOI 10.1039/C4CC02126F
Impact Factor 6.222
Authors

Lalit N. Goswami, Aslam A. Khan, Satish S. Jalisatgi, M. Frederick Hawthorne


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Abstract

The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine (19F) magnetic resonance spectroscopy (19F-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl)phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo-B122−-core via suitable linkers. The 19F-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.

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Notes

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