Trifluoromethylation of heterocycles in water at room temperature
Literature Information
James C. Fennewald, Bruce H. Lipshutz
Using a reaction medium containing nanoparticles consisting of commercially available TPGS-750-M in water, a combination of Langlois’ reagent and t-BuOOH can be used to effect trifluoromethylation of several heterocyclic arrays, including heteroaromatics. These reactions take place at ambient temperatures, and the aqueous medium can be recycled.
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