Highly atom-efficient and chemoselective reduction of ketones in the presence of aldehydes using heterogeneous catalysts
Literature Information
Yusuke Takahashi, Takato Mitsudome, Tomoo Mizugaki, Koichiro Jitsukawa
The first demonstration of a 100% atom-efficient selective reduction of less reactive ketones over aldehydes using heterogeneous catalysts is reported. Extremely high selectivities for intra- and intermolecular reductions of ketones over aldehydes were achieved. This system was also applicable to a column reactor, leading to a gram-scale synthesis.
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