Rapid self-healable poly(ethylene glycol) hydrogels formed by selective metal–phosphate interactions

Literature Information

Publication Date 2013-04-03
DOI 10.1039/C3CP50165E
Impact Factor 3.676
Authors

Mitsuhiro Ebara, Shinji Tanaka, Taka-Aki Asoh, Akihiko Kikuchi


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Abstract

Rapid self-healable and biocompatible hydrogels were prepared using the selective formation of metal–ligand interactions between selected metal ions and phosphate end groups of poly(ethylene glycol) (PEG). The phosphate-terminated branch of PEG was synthesized via a substitution reaction of the hydroxyl end groups using phosphoryl chloride. The gelation and gel properties including rheological properties can be tuned by the careful selection of metal ions, branch numbers, and temperature. Especially, the gels rapidly formed by trivalent metal ions such as Fe3+, V3+, Al3+, Ti3+, and Ga3+ have relatively small ionic radii. The ligand substitution rates also affected the repeatable autonomic healing ability. We have also demonstrated a gel–sol/sol–gel transition by switching the redox states of Fe3+/Fe2+ ions. Learning from biological systems, the proposed phosphate–metal ion based self-healable hydrogels could become an attractive candidate for various biomedical and environmental applications.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
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