Biofunctional micellar nanoparticles from peptide-b-polymer chimeras

Literature Information

Publication Date 2013-01-07
DOI 10.1039/C2PY21044D
Impact Factor 5.582
Authors

Anne-Laure Wirotius, Katell Bathany, Emmanuel Ibarboure, Olivia Condassamy, Sébastien Lecommandoux


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Abstract

We describe the precision synthesis and characterization of amphiphilic peptide-b-polymer chimeras encoding, at the molecular level, self-assembly properties and biological functions, presently cell membrane penetrating motifs (Tat peptide). Self-assembled micellar nanoparticles obtained from a series of Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) chimeras with tunable hydrophilic fractions were finely characterized in order to establish chimera–nanoparticle structure relationships. Well-defined nanoparticles with diameters ranging from 22 to 40 nm could be obtained by direct self-assembly in buffer.

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Source Journal

Polymer Chemistry

Polymer Chemistry
CiteScore: 8.6
Self-citation Rate: 7.3%
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