Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS‡

Literature Information

Publication Date 2012-10-11
DOI 10.1039/C2GC36305D
Impact Factor 10.182
Authors

Vishal Kumar, Sushila Sharma, Upendra Sharma, Bikram Singh, Neeraj Kumar


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Abstract

AlCl3 has been employed for highly chemoselective reductive amination of carbonyl compounds in ethanol using polymethylhydrosiloxane as an inexpensive, stable and safe reducing agent without an inert atmosphere. A large range of functional groups such as nitro, carboxylic acid, acetyl, nitrile, halogen, methoxy, alkene and heterocycles were well tolerated. AlCl3 also catalyzed tandem amination–amidation of 2-carboxybenzaldehyde with different amines to afford N-substituted isoindolinones. The catalyst can be recycled at least three times without any significant effect on activity and selectivity.

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