Magnetic field induced aggregation of nanoparticles for sensitive molecular detection

Literature Information

Publication Date 2011-01-14
DOI 10.1039/C0CP02055A
Impact Factor 3.676
Authors

Bong-Hyun Jun, Gunsung Kim, Jongho Baek, Homan Kang, Taeho Kim, Taeghwan Hyeon


View Original

Abstract

A molecular detection method utilizing the magnetically induced aggregation of silver nanoparticle (NP)-embedded silica NPs for SERS activation is described. Here, silver embedded magnetic NPs (Ag-M-dots) composed of a magnetic core and silica shells, on whose surface silver NPs were formed, were used. Because the magnetic field induced aggregated Ag-M-dots exhibit a strong SERS signal compared to the dispersed Ag-M-dots, the system allows for the detection of adsorbed Raman label compound even at the 100 fM level. Adenine was tested as a model biocompound and its Raman spectrum could be observed at concentrations as low as 1 pM. The experimental results were supported by the theoretical calculations.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
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