Solid-phase based total synthesis of Jasplakinolide by ring-closing metathesis
Literature Information
Tai-Shan Hu
The study of classical ring-closing metathesis and relay ring-closing metathesis in a total synthesis of Jasplakinolide and its desbromo analog is described.
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![4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1) structure 4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/143/1431697-96-9-619c.webp)