Effects of titanium(iv) ions on human monocyte-derived dendritic cells
Literature Information
Peta Clode, Martin Saunders
Orthopaedic metal implants composed of titanium are routinely used in bone fracture repair and for joint replacement therapies. A considerable fraction of implant recipients are unable to benefit due to implant failure resulting from aseptic loosening, while others may experience cutaneous sensitivity to titanium after implantation. An adaptive immune reactivity towards titanium ions, originating from the biocorrosion of the implants, could play a role. As an initiator of the adaptive immune response, dendritic cells (DC) were studied for uptake and characteristics after titanium exposure. Energy filtered transmission electron microscopy showed uptake of titanium(IV) (Ti(IV)) ions by DCsin vitro and co-localisation with phosphorus-rich cell structures of the DC membranes (phospholipids), cytoplasm (ribosomes and phosphorylated proteins) and the nucleus (DNA). DC maturation and function were investigated by measuring cell surface marker expression by flow cytometry. After exposure, DCs showed a decrease in MHC class II (HLA-DR), co-stimulatory molecules (CD40, CD80 & CD86) and chemokine receptors (CCR) 6 and CCR7 but an increase in CCR4 after Ti(IV) treatment. However, Ti(IV) treated DCs had an increased stimulatory capacity towards allogenic lymphocytes. A Ti(IV) concentration dependant increase of IL-12p70 was observed amidst decrease of the other measured cytokines (TGF-β1 and TGF-β2). Hence, Ti(IV) alters DC properties, resulting in an enhanced T lymphocyte reactivity and deviation towards a Th1 type immune response. This effect may be responsible for the inflammatory side effects of titanium implants seen in patients.
Recommended Journals

Faraday Discussions

Journal of Enzyme inhibition and Medicinal Chemistry

Mini-Reviews in Medicinal Chemistry

Physical Chemistry Chemical Physics

Angewandte Chemie International Edition

Foundations of Chemistry

Advanced Engineering Materials

Molecules

Coloration Technology

Photochemical & Photobiological Sciences
Related Literature
Measurement and PC-SAFT modelling of three-phase behaviour
Iago Rodríguez-Palmeiro, Oscar Rodríguez, Ana Soto, Christoph Held
DOI: 10.1039/C4CP04336G
Stability and spinodal decomposition of the solid-solution phase in the ruthenium–cerium–oxide electro-catalyst
Yanmei Li, Xin Wang, Yanqun Shao, Bo Wu, Zhongzhi Tang, Wei Lin
DOI: 10.1039/C4CP04131C
Adsorption of metal adatoms on single-layer phosphorene
Oleksandr I. Malyi, Ping Wu
DOI: 10.1039/C4CP03890H
Surface redox chemistry and mechanochemistry of insulating polystyrene nanospheres
Thomas S. Varley, Martin Rosillo-Lopez, Sandeep Sehmi, Nathan Hollingsworth, Katherine B. Holt
DOI: 10.1039/C4CP03938F
Formation of dibenzofuran, dibenzo-p-dioxin and their hydroxylated derivatives from catechol
Mohammednoor Altarawneh, Bogdan Z. Dlugogorski
DOI: 10.1039/C4CP04168B
Water and polymer dynamics in a model polysaccharide hydrogel: the role of hydrophobic/hydrophilic balance
V. Venuti, F. D'Amico, A. Gessini, F. Castiglione, C. Punta, L. Melone, V. Crupi, D. Majolino, F. Trotta, C. Masciovecchio
DOI: 10.1039/C4CP04045G
Complex behaviour of vacancy point-defects in SrRuO3 thin films
Henning Schraknepper, Christoph Bäumer, Regina Dittmann, Roger A. De Souza
DOI: 10.1039/C4CP03632H
Schiff base ligands and their transition metal complexes in the mixtures of ionic liquid + organic solvent: a thermodynamic study
Hemayat Shekaari, Amir Kazempour, Maryam Khoshalhan
DOI: 10.1039/C4CP04432K
You might also like
What is Ethyl 3-cyclohexylpropanoate (CAS: 10094-36-7)?
Ethyl 3-cyclohexylpropanoate is a clear, colorless to light yellow liquid with a...
How should waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl)nicotinic acid (CAS: 34783-31-8) be handled?
Waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl...
How should waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) be handled?
Waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) sho...
What precautions should be taken when handling Chloroac-nle-oh (CAS: 56787-36-1)?
When handling Chloroac-nle-oh (CAS: 56787-36-1), it is essential to wear appropr...
What industries use Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 752244-05-6)?
Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate is primarily used in the...
Are there alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis?
Alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis ...
How should waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) be handled?
Waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) should be managed...
What industries use 1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9)?
1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9) is used in various ...
Are there alternatives to 3-Bromo-5-(N-Boc)aminomethylisoxazole (CAS: 903131-45-3) in synthesis?
There are alternative reagents and compounds that can be used in the synthesis o...
What is Tungsten(IV) oxide (CAS: 12036-22-5)?
Tungsten(IV) oxide, also known as tungsten dioxide, is a chemical compound with ...
Source Journal
Metallomics

Metallomics publishes cutting-edge investigations aimed at elucidating the identification, distribution, dynamics, role and impact of metals and metalloids in biological systems. Studies that address the “what, where, when, how and why” of these inorganic elements in cells, tissues, organisms, and various environmental niches are welcome, especially those employing multidisciplinary approaches drawn from the analytical, bioinorganic, medicinal, environmental, biophysical, cell biology, plant biology and chemical biology communities. We are particularly interested in articles that enhance our chemical and/or physical understanding of the molecular mechanisms of metal-dependent life processes, and those that probe the common space between metallomics and other ‘omics approaches to uncover new insights into biological processes. Metallomics seeks to position itself at the forefront of those advances in analytical chemistry destined to clarify the enormous complexity of biological systems. As such, we particularly welcome those papers that outline cutting-edge analytical technologies, e.g., in the development and application of powerful new imaging, spectroscopic and mass spectrometric modalities. Work that describes new insights into metal speciation, trafficking and dynamics in complex systems or as a function of microenvironment are also strongly encouraged. Studies that examine the interconnectivity of metal-dependent processes with systems level responses relevant to organismal health or disease are also strongly encouraged, for example those that probe the effect of chemical exposure on metal homeostasis or the impact of metal-based drugs on cellular processes.




