Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Literature Information

Publication Date 2008-11-12
DOI 10.1039/B815918A
Impact Factor 6.222
Authors

Ahn Na Koo, Hong Jae Lee, Sung Eun Kim, Jeong Ho Chang, Chiyoung Park, Chulhee Kim, Jae Hyung Park, Sang Cheon Lee


View Original

Abstract

We report biocompatible, cell-permeable core–shell–corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

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