Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)2Zn·2MgCl2·2LiCl

Literature Information

Publication Date 2008-11-04
DOI 10.1039/B815903C
Impact Factor 6.222
Authors

Stefan Wunderlich, Paul Knochel


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Abstract

3,6-Dichloropyridazine undergoes a smooth metallation using (tmp)2Zn·2MgCl2·2LiCl. The resulting bis-organozinc species react with various electrophiles; subsequent functionalization via a second metallation proceeds readily; further reactions with hydrazine lead to highly substituted pyrazolo[3,4-c]pyridazines derivatives.

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Chemical Communications
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