Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers

Literature Information

Publication Date 2008-09-30
DOI 10.1039/B814576H
Impact Factor 6.222
Authors

William C. Drewe, Stephen Neidle


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Abstract

A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed ‘click’ chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines.

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