Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers
Literature Information
Publication Date
2008-09-30
DOI
10.1039/B814576H
Impact Factor
6.222
Authors
William C. Drewe, Stephen Neidle
View Original
Abstract
A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed ‘click’ chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines.
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Source Journal
Chemical Communications
CiteScore:
8.6
Self-citation Rate:
4.7%
Articles per Year:
2458
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(3R)-4-(4-Chlorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid
CAS Number:
218608-96-9
Molecular Formula:
C15H20ClNO4
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Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with 1-pyrrolidineethanol (1:1)
CAS Number:
119623-66-4
Molecular Formula:
C20H24Cl2N2O3
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