Highly enantio- and diastereoselective organocatalytic cascade aza-Michael–Michael reactions: a direct method for the synthesis of trisubstituted chiral pyrrolidines

Literature Information

Publication Date 2008-09-30
DOI 10.1039/B812464G
Impact Factor 6.222
Authors

Hao Li, Liansuo Zu, Hexin Xie, Jian Wang, Wei Wang


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Abstract

An unprecedented highly enantio- and diastereoselective cascade aza-Michael–Michael reaction of α,β-unsaturated aldehydes with trans-γ-Ts protected amino α,β-unsaturated ester has been developed; the simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, serves as a powerful access to highly functionalized trisubstituted chiral pyrrolidines.

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