Highly enantio- and diastereoselective organocatalytic cascade aza-Michael–Michael reactions: a direct method for the synthesis of trisubstituted chiral pyrrolidines

Literature Information

Publication Date 2008-09-30
DOI 10.1039/B812464G
Impact Factor 6.222
Authors

Hao Li, Liansuo Zu, Hexin Xie, Jian Wang, Wei Wang


View Original

Abstract

An unprecedented highly enantio- and diastereoselective cascade aza-Michael–Michael reaction of α,β-unsaturated aldehydes with trans-γ-Ts protected amino α,β-unsaturated ester has been developed; the simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, serves as a powerful access to highly functionalized trisubstituted chiral pyrrolidines.

Related Literature

Direct synthesis of poly(p-phenyleneethynylene)s from calcium carbide

Nopparat Thavornsin, Mongkol Sukwattanasinitt, Sumrit Wacharasindhu

2013-08-12 Communication

DOI: 10.1039/C3PY01068F

Contents list

2021-03-19 Front/Back Matter

DOI: 10.1039/C3PY90082G

Cationic polythiophenes as responsive DNA-binding polymers

Webster L. Santos, John B. Matson, Regina C. So

2013-09-23 Communication

DOI: 10.1039/C3PY01069D

Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

Robert Pola, Alena Braunová, Richard Laga, Michal Pechar, Karel Ulbrich

2013-10-29 Paper

DOI: 10.1039/C3PY01376F

Photo-induced cobalt-mediated radical polymerization of vinyl acetate

Xuelang Miao, Wei Zhu, Zhengbiao Zhang, Wei Zhang, Xiulin Zhu, Jian Zhu

2013-08-28 Paper

DOI: 10.1039/C3PY00913K

Microporous organic polymers with acetal linkages: synthesis, characterization, and gas sorption properties

Li-Min Zhang, Tao Wang, Bao-Hang Han

2013-08-22 Paper

DOI: 10.1039/C3PY00854A

Supramolecular polymer fabricated by click polymerization from supramonomer

Liulin Yang, Xiaoguang Liu, Xinxin Tan, Hui Yang, Zhiqiang Wang, Xi Zhang

2013-09-10 Communication

DOI: 10.1039/C3PY01161E

One pot synthesis and characterization of novel poly(ether ester) mutiblock copolymers containing poly(tetramethylene oxide) and poly(ethylene terephthalate)

Weichun Huang, Yingbo Wan, Jianying Chen, Qiaozhen Xu, Xiaohong Li, Xiaoming Yang, Yaowen Li, Yingfeng Tu

2013-10-18 Paper

DOI: 10.1039/C3PY00932G

You might also like

Compound Q&A

What are the main uses of 1H-Indazole-6-carbonitrile (CAS: 141290-59-7)?

1H-Indazole-6-carbonitrile finds applications in pharmaceuticals, where it serve...

141290-59-71H-Indazole-6-carbon...
Compound Q&A

How should waste containing Dioctyl (2E)-2-butenedioate (CAS: 2997-85-5) be handled?

Waste containing Dioctyl (2E)-2-butenedioate (CAS: 2997-85-5) should be collecte...

2997-85-5Dioctyl (2E)-2-buten...
Compound Q&A

What industries use Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide (CAS: 68291-98-5)?

Sodium [(1,2-benzoxazol-3-ylmethyl)sulfonyl]azanide is primarily used in pharmac...

68291-98-5Sodium [(1,2-benzoxa...
Compound Q&A

Are there alternatives to Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-pyridinedicarboxylate (CAS: 741709-66-0) in synthesis?

Dimethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-pyridinedicarboxyla...

741709-66-0Dimethyl 4-(4,4,5,5-...
Compound Q&A

How should waste containing 2-Fluoro-6-hydrazinopyridine (CAS: 80714-39-2) be handled?

Waste containing 2-Fluoro-6-hydrazinopyridine (CAS: 80714-39-2) should be manage...

80714-39-22-Fluoro-6-hydrazino...
Compound Q&A

What is 6-Formyl-2-pyridinecarboxylic acid (CAS: 499214-11-8)?

6-Formyl-2-pyridinecarboxylic acid is an organic compound with the molecular for...

499214-11-86-Formyl-2-pyridinec...
900874-91-13-(3,4-dimethoxyphen...
Compound Q&A

How is 9H-Tribenzo[b,d,f]azepine (CAS: 29875-73-8) typically synthesized?

9H-Tribenzo[b,d,f]azepine is typically synthesized via a multi-step process invo...

29875-73-89H-Tribenzo[b,d,f]az...
Compound Q&A

How is 1-Cyclopropyl-7-ethoxy-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid (CAS: 1797982-51-4) typically synthesized?

1-Cyclopropyl-7-ethoxy-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxyli...

1797982-51-41-Cyclopropyl-7-etho...
Compound Q&A

How should waste containing Methyl 3-oxo-1,2,3,4-tetrahydro-6-quinoxalinecarboxylate (CAS: 671820-52-3) be handled?

Waste containing Methyl 3-oxo-1,2,3,4-tetrahydro-6-quinoxalinecarboxylate (CAS: ...

671820-52-3Methyl 3-oxo-1,2,3,4...

Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.