Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging

Literature Information

Publication Date 2008-09-12
DOI 10.1039/B810403D
Impact Factor 6.222
Authors

Ute Neugebauer, Yann Pellegrin, Marc Devocelle, William Signac, Niamh Moran


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Abstract

Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru–Ahx–R5), and one to eight arginine residues, (Ru–Ahx–R8); both complexes exhibit long-lived, intense, and oxygen-sensitive luminescence; (Ru–R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for its permeablisation.

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