Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

Literature Information

Publication Date 2008-07-18
DOI 10.1039/B807016D
Impact Factor 6.222
Authors

Silvia Marchesan, Derek Macmillan


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Abstract

GDP-2-, 3-, 4- or 6-azidomannoses can be successfully prepared from the corresponding azidomannose-1-phosphates and GTP using the enzyme GDP-Mannosepyrophosphorylase (GDP-ManPP) from Salmonella enterica and may serve as useful probes for mannosyltransferase activity.

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