Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts

Literature Information

Publication Date 2008-06-24
DOI 10.1039/B806389C
Impact Factor 6.222
Authors

Yuichiro Kishi, Hirokatsu Nagura, Shinsuke Inagi, Toshio Fuchigami


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Abstract

Prins cyclization of homoallylic alcohols, thiols, and amines with various aldehydes in an ionic liquid HF salt (Et4NF·5HF) afforded the corresponding 4-fluorinated heterocycles in excellent yields.

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