Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24]6− polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate

Literature Information

Publication Date 2007-11-16
DOI 10.1039/B714860G
Impact Factor 6.222
Authors

Els Cartuyvels, Gregory Absillis, Tatjana N. Parac-Vogt


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Abstract

The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl)phosphate (BNPP) is promoted by the heptamolybdate anion [Mo7O24]6− with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.

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