Scaffolded amino acids as a close structural mimic of type-3 copper binding sites

Literature Information

Publication Date 2007-11-02
DOI 10.1039/B709400K
Impact Factor 6.222
Authors

H. Bauke Albada, Fouad Soulimani, Bert M. Weckhuysen, Rob M. J. Liskamp


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Abstract

We report the use of triazacyclophane (TAC)-scaffolded amino acids as a structural mimic for 3-histidine metal-binding sites in metalloproteins, especially for the mimicry of type-3 copper binding sites as are present in hemocyanin, tyrosinase and catechol oxidase.

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